Brett Houk Selected Research

Neoplasms (Cancer)

12/2017	A Multi-Arm Phase I Study of the PI3K/mTOR Inhibitors PF-04691502 and Gedatolisib (PF-05212384) plus Irinotecan or the MEK Inhibitor PD-0325901 in Advanced Cancer.
7/2016	A randomized phase II non-comparative study of PF-04691502 and gedatolisib (PF-05212384) in patients with recurrent endometrial cancer.
10/2015	A phase I study of VS-6063, a second-generation focal adhesion kinase inhibitor, in patients with advanced solid tumors.

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Brett Houk Research Topics

Disease

3	Neoplasms (Cancer) 12/2017 - 10/2015
3	Fatigue 07/2016 - 03/2010
2	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 10/2022 - 01/2021
2	Endometrial Neoplasms (Endometrial Cancer) 12/2017 - 07/2016
2	Hand-Foot Syndrome 12/2010 - 03/2010
2	Renal Cell Carcinoma (Grawitz Tumor) 12/2010 - 03/2010
1	Sarcoma (Soft Tissue Sarcoma) 02/2024
1	Ovarian Neoplasms (Ovarian Cancer) 12/2017
1	Colorectal Neoplasms (Colorectal Cancer) 12/2017
1	Diarrhea 07/2016
1	Vomiting 07/2016
1	Inflammation (Inflammations) 07/2016
1	Dysgeusia (Parageusia) 07/2016
1	Nausea 07/2016
1	Pneumonia (Pneumonitis) 07/2016
1	Hypertension (High Blood Pressure) 03/2010

Drug/Important Bio-Agent (IBA)

2	sotorasibIBA 02/2024 - 10/2022
2	gedatolisibIBA 12/2017 - 07/2016
2	2- amino- 8- (4- (2- hydroxyethoxy)cyclohexyl)- 6- (6- methoxypyridin- 3- yl)- 4- methylpyrido(2,3- d)pyrimidin- 7(8H)- oneIBA 12/2017 - 07/2016
2	Lipase (Acid Lipase)FDA Link 12/2010 - 03/2010
2	Sunitinib (Sutent)FDA Link 12/2010 - 03/2010
1	Mutant Proteins (Protein, Mutant)IBA 02/2024
1	Proteins (Proteins, Gene)FDA Link 02/2024
1	CrizotinibIBA 01/2021
1	alectinibIBA 01/2021
1	ceritinibIBA 01/2021
1	lorlatinibIBA 01/2021
1	Anaplastic Lymphoma KinaseIBA 01/2021
1	Protein-Tyrosine Kinases (Tyrosine Kinase)IBA 01/2021
1	MTOR InhibitorsIBA 12/2017
1	mirdametinibIBA 12/2017
1	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 12/2017
1	Irinotecan (Camptosar)FDA LinkGeneric 12/2017
1	PlatinumIBA 07/2016
1	StathminIBA 07/2016
1	defactinibIBA 10/2015
1	Focal Adhesion Protein-Tyrosine KinasesIBA 10/2015
1	CytokinesIBA 12/2010

Therapy/Procedure

1	Therapeutics 01/2021
1	Drug Therapy (Chemotherapy) 07/2016
1	Intravenous Infusions 07/2016